Impaired Clearance of Influenza A Virus in Obese, Leptin Receptor Deficient Mice Is Independent of Leptin Signaling in the Lung Epithelium and Macrophages

RATIONALE: During the recent H1N1 outbreak, obese patients had worsened lung injury and increased mortality. We used a murine model of influenza A pneumonia to test the hypothesis that leptin receptor deficiency might explain the enhanced mortality in obese patients. METHODS: We infected wild-type,...

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Detalhes bibliográficos
Main Authors: Radigan, Kathryn A., Morales-Nebreda, Luisa, Soberanes, Saul, Nicholson, Trevor, Nigdelioglu, Recep, Cho, Takugo, Chi, Monica, Hamanaka, Robert B., Misharin, Alexander V., Perlman, Harris, Budinger, G. R. Scott, Mutlu, Gökhan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169489/
https://ncbi.nlm.nih.gov/pubmed/25232724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108138
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