Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome organization. Using the super-resolution microscopy methods of OligoSTORM and OligoDN...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Nir, Guy, Farabella, Irene, Pérez Estrada, Cynthia, Ebeling, Carl G., Beliveau, Brian J., Sasaki, Hiroshi M., Lee, S. Dean, Nguyen, Son C., McCole, Ruth B., Chattoraj, Shyamtanu, Erceg, Jelena, AlHaj Abed, Jumana, Martins, Nuno M. C., Nguyen, Huy Q., Hannan, Mohammed A., Russell, Sheikh, Durand, Neva C., Rao, Suhas S. P., Kishi, Jocelyn Y., Soler-Vila, Paula, Di Pierro, Michele, Onuchic, José N., Callahan, Steven P., Schreiner, John M., Stuckey, Jeff A., Yin, Peng, Aiden, Erez Lieberman, Marti-Renom, Marc A., Wu, C.-ting
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324821/
https://ncbi.nlm.nih.gov/pubmed/30586358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007872
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