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De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell type. Here, we show that this chromatin architecture can be predicted de novo using epigenetic data derived from chromatin immunoprecipitation-sequencing (ChIP-Seq). We exploit the idea that chromosomes e...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Di Pierro, Michele, Cheng, Ryan R., Lieberman Aiden, Erez, Wolynes, Peter G., Onuchic, José N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699090/
https://ncbi.nlm.nih.gov/pubmed/29087948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714980114
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