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De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell type. Here, we show that this chromatin architecture can be predicted de novo using epigenetic data derived from chromatin immunoprecipitation-sequencing (ChIP-Seq). We exploit the idea that chromosomes e...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Di Pierro, Michele, Cheng, Ryan R., Lieberman Aiden, Erez, Wolynes, Peter G., Onuchic, José N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699090/
https://ncbi.nlm.nih.gov/pubmed/29087948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714980114
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