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De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell type. Here, we show that this chromatin architecture can be predicted de novo using epigenetic data derived from chromatin immunoprecipitation-sequencing (ChIP-Seq). We exploit the idea that chromosomes e...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Di Pierro, Michele, Cheng, Ryan R., Lieberman Aiden, Erez, Wolynes, Peter G., Onuchic, José N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699090/
https://ncbi.nlm.nih.gov/pubmed/29087948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714980114
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