Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

PURPOSE: We have shown that the aged microenvironment increases melanoma metastasis, and decreases response to targeted therapy, and here we queried response to anti-PD1. EXPERIMENTAL DESIGN: We analyzed the relationship between age, response to anti-PD1, and prior therapy in 538 patients. We used m...

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Pubblicato in:Clin Cancer Res
Autori principali: Kugel, Curtis H., Douglass, Stephen M., Webster, Marie R., Kaur, Amanpreet, Liu, Qin, Yin, Xiangfan, Weiss, Sarah A., Darvishian, Farbod, Al-Rohil, Rami N., Ndoye, Abibatou, Behera, Reeti, Alicea, Gretchen M., Ecker, Brett L., Fane, Mitchell, Allegrezza, Michael J., Svoronos, Nikolaos, Kumar, Vinit, Wang, Daniel Y., Somasundaram, Rajasekharan, Hu-Lieskovan, Siwen, Ozgun, Alpaslan, Herlyn, Meenhard, Conejo-Garcia, Jose R., Gabrilovich, Dmitry, Stone, Erica L., Nowicki, Theodore S., Sosman, Jeffrey, Rai, Rajat, Carlino, Matteo S., Long, Georgina V., Marais, Richard, Ribas, Antoni, Eroglu, Zeynep, Davies, Michael A., Schilling, Bastian, Schadendorf, Dirk, Xu, Wei, Amaravadi, Ravi K., Menzies, Alexander M., McQuade, Jennifer L., Johnson, Douglas B., Osman, Iman, Weeraratna, Ashani T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324578/
https://ncbi.nlm.nih.gov/pubmed/29898988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1116
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