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CADD: predicting the deleteriousness of variants throughout the human genome

Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders. CADD is an integrative annotation built from more than 60...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Rentzsch, Philipp, Witten, Daniela, Cooper, Gregory M, Shendure, Jay, Kircher, Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323892/
https://ncbi.nlm.nih.gov/pubmed/30371827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1016
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