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CADD: predicting the deleteriousness of variants throughout the human genome

Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders. CADD is an integrative annotation built from more than 60...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Rentzsch, Philipp, Witten, Daniela, Cooper, Gregory M, Shendure, Jay, Kircher, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323892/
https://ncbi.nlm.nih.gov/pubmed/30371827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1016
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