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CADD: predicting the deleteriousness of variants throughout the human genome

Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders. CADD is an integrative annotation built from more than 60...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Rentzsch, Philipp, Witten, Daniela, Cooper, Gregory M, Shendure, Jay, Kircher, Martin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323892/
https://ncbi.nlm.nih.gov/pubmed/30371827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1016
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