The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

OBJECTIVES: GPR142, which is highly expressed in pancreatic islets, has recently been deorphanized as a receptor for aromatic amino acids; however, its physiological role and pharmacological potential is unclear. METHODS AND RESULTS: We find that GPR142 is expressed not only in β- but also in α-cell...

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Publicat a:Mol Metab
Autors principals: Rudenko, Olga, Shang, Jin, Munk, Alexander, Ekberg, Jeppe P., Petersen, Natalia, Engelstoft, Maja S., Egerod, Kristoffer L., Hjorth, Siv A., Wu, Margaret, Feng, Yue, Zhou, Yun-Ping, Mokrosinski, Jacek, Thams, Peter, Reimann, Frank, Gribble, Fiona, Rehfeld, Jens F., Holst, Jens J., Treebak, Jonas T., Howard, Andrew D., Schwartz, Thue W.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323244/
https://ncbi.nlm.nih.gov/pubmed/30472415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.10.012
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