β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia

Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On system under the control of the proinsulin promoter...

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Autors principals: Egerod, Kristoffer L., Jin, Chunyu, Petersen, Pia Steen, Wierup, Nils, Sundler, Frank, Holst, Birgitte, Schwartz, Thue W.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227460/
https://ncbi.nlm.nih.gov/pubmed/22164158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/401258
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