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Z-DNA and Z-RNA in human disease
Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral orthologs regulating innate immunity. Loss-of-function mutations in ADAR p150 allow persistent activation of the interferon system by Alu dsRN...
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| Pubblicato in: | Commun Biol |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6323056/ https://ncbi.nlm.nih.gov/pubmed/30729177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0237-x |
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