The solution structure of the Zα domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA

Double-stranded RNA deaminase I (ADAR1) contains the Z-DNA binding domain Zα. Here we report the solution structure of free Zα and map the interaction surface with Z-DNA, confirming roles previously assigned to residues by mutagenesis. Comparison with the crystal structure of the (Zα)(2)/Z-DNA compl...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Schade, Markus, Turner, Christopher J., Kühne, Ronald, Schmieder, Peter, Lowenhaupt, Ky, Herbert, Alan, Rich, Alexander, Oschkinat, Hartmut
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22950/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10535945/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12465
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