The solution structure of the Zα domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA

Double-stranded RNA deaminase I (ADAR1) contains the Z-DNA binding domain Zα. Here we report the solution structure of free Zα and map the interaction surface with Z-DNA, confirming roles previously assigned to residues by mutagenesis. Comparison with the crystal structure of the (Zα)(2)/Z-DNA compl...

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Détails bibliographiques
Auteurs principaux: Schade, Markus, Turner, Christopher J., Kühne, Ronald, Schmieder, Peter, Lowenhaupt, Ky, Herbert, Alan, Rich, Alexander, Oschkinat, Hartmut
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1999
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC22950/
https://ncbi.nlm.nih.gov/pubmed/10535945
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