The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences.

Z-DNA, the left-handed conformer of DNA, is stabilized by the negative supercoiling generated during the movement of an RNA polymerase through a gene. Recently, we have shown that the editing enzyme ADAR1 (double-stranded RNA adenosine deaminase, type 1) has two Z-DNA binding motifs, Zalpha and Zbet...

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Detalhes bibliográficos
Main Authors: Herbert, A, Schade, M, Lowenhaupt, K, Alfken, J, Schwartz, T, Shlyakhtenko, L S, Lyubchenko, Y L, Rich, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC147729/
https://ncbi.nlm.nih.gov/pubmed/9671809
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