Structure-function analysis of the Z-DNA-binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the (alpha + beta) family of helix-turn-helix proteins.

RNA editing alters pre-mRNA through site-selective adenosine deamination, which results in codon changes that lead to the production of novel proteins. An enzyme that catalyzes this reaction, double-stranded RNA adenosine deaminase (ADAR1), contains two N-terminal Z-DNA-binding motifs, Zalpha and Zb...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Schade, M, Turner, C J, Lowenhaupt, K, Rich, A, Herbert, A
Format: Artigo
Langue:Inglês
Publié: 1999
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171140/
https://ncbi.nlm.nih.gov/pubmed/9889202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.2.470
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