Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors

Matriptase is a member of the type-II transmembrane serine protease (TTSP) family and plays a crucial role in the development and maintenance of epithelial tissues. As all chymotrypsin-like serine proteases, matriptase is synthesized as a zymogen (proform), requiring a cleavage event for full activi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tamberg, Trine, Hong, Zebin, De Schepper, Daphné, Skovbjerg, Signe, Dupont, Daniel M., Vitved, Lars, Schar, Christine R., Skjoedt, Karsten, Vogel, Lotte K., Jensen, Jan K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322904/
https://ncbi.nlm.nih.gov/pubmed/30409910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004126
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