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Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis

Caspases are cysteine–aspartic proteases involved in the regulation of programmed cell death (apoptosis) and a number of other biological processes. Despite overall similarities in structure and active-site composition, caspases show striking selectivity for particular protein substrates. Exosites a...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: MacPherson, Derek J., Mills, Caitlyn L., Ondrechen, Mary Jo, Hardy, Jeanne A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322879/
https://ncbi.nlm.nih.gov/pubmed/30420425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005914
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