Structural interpretation of DNA-protein hydroxyl-radical footprinting experiments with high resolution using HYDROID

Hydroxyl-radical footprinting (HRF) is a powerful method to probe structures of nucleic acid-protein complexes with single nucleotide resolution in solution. To tap the full quantitative potential of HRF, we describe a protocol HYDroxyl-Radical footprinting Interpretation for DNA (HYDROID) to quanti...

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Publicado en:Nat Protoc
Autores principales: Shaytan, Alexey K., Xiao, Hua, Armeev, Grigoriy A., Gaykalova, Daria A., Komarova, Galina A., Wu, Carl, Studitsky, Vasily M., Landsman, David, Panchenko, Anna R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322412/
https://ncbi.nlm.nih.gov/pubmed/30341436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41596-018-0048-z
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