Prevalence of BRCA1 and BRCA2 pathogenic variants in a large, unselected breast cancer cohort

Breast cancer patients with BRCA1/2‐driven tumors may benefit from targeted therapy. It is not clear whether current BRCA screening guidelines are effective at identifying these patients. The purpose of our study was to evaluate the prevalence of inherited BRCA1/2 pathogenic variants in a large, cli...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Li, Jingmei, Wen, Wei Xiong, Eklund, Martin, Kvist, Anders, Eriksson, Mikael, Christensen, Helene Nordahl, Torstensson, Astrid, Bajalica‐Lagercrantz, Svetlana, Dunning, Alison M., Decker, Brennan, Allen, Jamie, Luccarini, Craig, Pooley, Karen, Simard, Jacques, Dorling, Leila, Easton, Douglas F., Teo, Soo‐Hwang, Hall, Per, Borg, Åke, Grönberg, Henrik, Czene, Kamila
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2018
Assuntos:
Cancer Therapy and Prevention
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320715/
https://ncbi.nlm.nih.gov/pubmed/30175445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31841
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