Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic

BACKGROUND: A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the ratio between somatic and germline BRCA1/2 mutations in unselected breast cancer patients are currently unclear. PATIENTS AN...

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Publicado en:Ann Oncol
Main Authors: Winter, C., Nilsson, M. P., Olsson, E., George, A. M., Chen, Y., Kvist, A., Törngren, T., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Jönsson, G., Grabau, D., Malmberg, M., Kristoffersson, U., Rehn, M., Gruvberger-Saal, S. K., Larsson, C., Borg, Å., Loman, N., Saal, L. H.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959927/
https://ncbi.nlm.nih.gov/pubmed/27194814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw209
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