Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers

Homologous recombination deficiency (HRD) is a defining characteristic in BRCA-deficient breast tumors caused by genetic or epigenetic alterations in key pathway genes. We investigated the frequency of BRCA1 promoter hypermethylation in 237 triple-negative breast cancers (TNBCs) from a population-ba...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Glodzik, Dominik, Bosch, Ana, Hartman, Johan, Aine, Mattias, Vallon-Christersson, Johan, Reuterswärd, Christel, Karlsson, Anna, Mitra, Shamik, Niméus, Emma, Holm, Karolina, Häkkinen, Jari, Hegardt, Cecilia, Saal, Lao H., Larsson, Christer, Malmberg, Martin, Rydén, Lisa, Ehinger, Anna, Loman, Niklas, Kvist, Anders, Ehrencrona, Hans, Nik-Zainal, Serena, Borg, Åke, Staaf, Johan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385112/
https://ncbi.nlm.nih.gov/pubmed/32719340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17537-2
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