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Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation
Central to CD8(+) Tcell-mediated immunity is the recognition of peptide-major histocompatibility complex class I (p-MHC I) proteins displayed by antigen-presenting cells. Chaperone-mediated loading of high-affinity peptides onto MHC I is a key step in the MHC I antigen presentation pathway. However,...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6320693/ https://ncbi.nlm.nih.gov/pubmed/29025991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao5154 |
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