Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle

Chaperones TAPBPR and tapasin associate with class-I major histocompatibility complexes (MHC-I) to promote optimization (editing) of peptide cargo. Here, we use solution NMR to investigate the mechanism of peptide exchange. We identify TAPBPR-induced conformational changes on conserved MHC-I molecul...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: McShan, Andrew C., Natarajan, Kannan, Kumirov, Vlad K., Flores-Solis, David, Jiang, Jiansheng, Badstübner, Mareike, Toor, Jugmohit S., Bagshaw, Clive R., Kovrigin, Evgenii L., Margulies, David H., Sgourakis, Nikolaos G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202177/
https://ncbi.nlm.nih.gov/pubmed/29988068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0096-2
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