In crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase

In the catalytic reaction of copper amine oxidase, the protein-derived redox cofactor topaquinone (TPQ) is reduced by an amine substrate to an aminoresorcinol form (TPQ(amr)), which is in equilibrium with a semiquinone radical (TPQ(sq)). The transition from TPQ(amr) to TPQ(sq) is an endothermic proc...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Murakawa, Takeshi, Baba, Seiki, Kawano, Yoshiaki, Hayashi, Hideyuki, Yano, Takato, Kumasaka, Takashi, Yamamoto, Masaki, Tanizawa, Katsuyuki, Okajima, Toshihide
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320532/
https://ncbi.nlm.nih.gov/pubmed/30563857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811837116
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