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In crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase
In the catalytic reaction of copper amine oxidase, the protein-derived redox cofactor topaquinone (TPQ) is reduced by an amine substrate to an aminoresorcinol form (TPQ(amr)), which is in equilibrium with a semiquinone radical (TPQ(sq)). The transition from TPQ(amr) to TPQ(sq) is an endothermic proc...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6320532/ https://ncbi.nlm.nih.gov/pubmed/30563857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811837116 |
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