Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenstrom Macroglobulinemia.

PURPOSE: p21-activated kinase 4 (PAK4) plays a significant biological and functional role in a number of malignancies, including multiple myeloma (MM). Based on our promising findings in MM, we here characterize PAK4 expression and role in WM cells, as well effect of dual PAK4-NAMPT inhibitor (KPT-9...

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Udgivet i:Clin Cancer Res
Main Authors: Li, Na, Lopez, Michael A, Linares, Maria, Kumar, Subodh, Oliva, Stefania, Martinez-Lopez, Joaquin, Xu, Lian, Xu, Yan, Perini, Tommaso, Senapedis, William, Baloglu, Erkan, Shammas, Masood A., Hunter, Zachary, Anderson, Kenneth C, Treon, Steven P, Munshi, Nikhil C, Fulciniti, Mariateresa
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320280/
https://ncbi.nlm.nih.gov/pubmed/30206161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1776
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