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Modular Synthesis of Cell-Permeating 2-Ketoglutarate Esters

Cell-permeating esters of 2-ketoglutarate (2-KG) have been synthesized through a convergent sequence from two modules in two and three steps, respectively. This route provides access to a full series of mono- and disubstituted 2-KG esters, enabling us to define the effect of regioisomeric masking on...

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Publicat a:Org Lett
Autors principals: Zengeya, Thomas T., Kulkarni, Rhushikesh A., Meier, Jordan L.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320255/
https://ncbi.nlm.nih.gov/pubmed/25915096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b00737
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