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Thpok-independent repression of Runx3 by Gata3 during CD4(+) T-cell differentiation in the thymus

CD4(+) helper T cells are essential for immune responses and differentiate in the thymus from CD4(+)CD8(+) ‘double-positive’ (DP) thymocytes. The transcription factor Runx3 inhibits CD4(+) T-cell differentiation by repressing Cd4 gene expression; accordingly, Runx3 is not expressed in DP thymocytes...

詳細記述

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書誌詳細
出版年:Eur J Immunol
主要な著者: Xiong, Yumei, Castro, Ehydel, Yagi, Ryoji, Zhu, Jinfang, Lesourne, Renaud, Love, Paul E., Feigenbaum, Lionel, Bosselut, Rémy
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319927/
https://ncbi.nlm.nih.gov/pubmed/23310955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242944
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