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Thpok-independent repression of Runx3 by Gata3 during CD4(+) T-cell differentiation in the thymus
CD4(+) helper T cells are essential for immune responses and differentiate in the thymus from CD4(+)CD8(+) ‘double-positive’ (DP) thymocytes. The transcription factor Runx3 inhibits CD4(+) T-cell differentiation by repressing Cd4 gene expression; accordingly, Runx3 is not expressed in DP thymocytes...
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| Publicado no: | Eur J Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6319927/ https://ncbi.nlm.nih.gov/pubmed/23310955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242944 |
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