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The sequential activation of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4(+) NKT cells

While most CD4(+) T cells are MHC class II-restricted, a small subset, including CD1d-restricted ‘invariant’ iNKT cells, are selected on non-classical MHC-I or MHC-I-like molecules. We previously showed that the sequential activation of two zinc finger transcription factors, Gata3 and Thpok, promote...

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Detalhes bibliográficos
Main Authors: Wang, Lie, Carr, Tiffany, Xiong, Yumei, Wildt, Kathryn F., Zhu, Jinfang, Feigenbaum, Lionel, Bendelac, Albert, Bosselut, Rémy
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321374/
https://ncbi.nlm.nih.gov/pubmed/20706986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040534
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