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The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma
The transcription factor GATA3 is crucial for the differentiation of naïve CD4(+) T cells into T helper 2 (Th2) cells. Here we show that deletion of Gata3 allowed the appearance of interferon γ (IFNγ)-producing cells in the absence of interleukin-12 (IL-12) and IFNγ. Such IFNγ production was transcr...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867662/ https://ncbi.nlm.nih.gov/pubmed/20399120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.004 |
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