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The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma

The transcription factor GATA3 is crucial for the differentiation of naïve CD4(+) T cells into T helper 2 (Th2) cells. Here we show that deletion of Gata3 allowed the appearance of interferon γ (IFNγ)-producing cells in the absence of interleukin-12 (IL-12) and IFNγ. Such IFNγ production was transcr...

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Библиографические подробности
Главные авторы: Yagi, Ryoji, Junttila, Ilkka S., Wei, Gang, Urban, Joseph F., Zhao, Keji, Paul, William E., Zhu, Jinfang
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867662/
https://ncbi.nlm.nih.gov/pubmed/20399120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.004
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