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Crystallographic evidence for two‐metal‐ion catalysis in human pol η
Extensive evidence exists that DNA polymerases use two metal ions to catalyze the phosphoryl transfer reaction. Recently, competing evidence emerged, suggesting that a third metal ion, known as MnC, may be involved in catalysis. The binding of MnC was observed in crystal structures of the replicatio...
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| Publicado en: | Protein Sci |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley & Sons, Inc.
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6319759/ https://ncbi.nlm.nih.gov/pubmed/30368948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3541 |
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