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Dynamic coordination of two-metal-ions orchestrates λ-exonuclease catalysis
Metal ions at the active site of an enzyme act as cofactors, and their dynamic fluctuations can potentially influence enzyme activity. Here, we use λ-exonuclease as a model enzyme with two Mg(2+) binding sites and probe activity at various concentrations of magnesium by single-molecule-FRET. We find...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Commun |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group UK
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6199318/ https://ncbi.nlm.nih.gov/pubmed/30353000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06750-9 |
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