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Single molecule analysis reveals three phases of DNA degradation by an exonuclease

λ exonuclease degrades one strand of duplex DNA in the 5’-3’ direction to generate a 3’ overhang required for recombination. Its ability to hydrolyze thousands of nucleotides processively is attributed to its ring structure and most studies have focused on the processive phase. Here, we use single m...

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Detalhes bibliográficos
Main Authors: Lee, Gwangrog, Yoo, Jungmin, Leslie, Benjamin J., Ha, Taekjip
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097319/
https://ncbi.nlm.nih.gov/pubmed/21552271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.561
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