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Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
The well-known age-related mitochondrial dysfunction deeply affects heart because of the tissue’s large dependence on mitochondrial ATP provision. Our study revealed in aged rat heart a significant 25% decrease in mtDNA relative content, a significant 29% increase in the 4.8 Kb mtDNA deletion relati...
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| Publicado no: | Free Radic Biol Med |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6319621/ https://ncbi.nlm.nih.gov/pubmed/29969715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.06.041 |
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