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A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat
BACKGROUND: Mitochondrial Transcription Factor A (TFAM) is regarded as a histone-like protein of mitochondrial DNA (mtDNA), performing multiple functions for this genome. Aging affects mitochondria in a tissue-specific manner and only calorie restriction (CR) is able to delay or prevent the onset of...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4335656/ https://ncbi.nlm.nih.gov/pubmed/24631828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.03.004 |
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