A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat

BACKGROUND: Mitochondrial Transcription Factor A (TFAM) is regarded as a histone-like protein of mitochondrial DNA (mtDNA), performing multiple functions for this genome. Aging affects mitochondria in a tissue-specific manner and only calorie restriction (CR) is able to delay or prevent the onset of...

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Udgivet i:Biochim Biophys Acta
Main Authors: Picca, Anna, Pesce, Vito, Fracasso, Flavio, Joseph, Anna-Maria, Leeuwenburgh, Christiaan, Lezza, Angela Maria Serena
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335656/
https://ncbi.nlm.nih.gov/pubmed/24631828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.03.004
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