Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver

Aging affects mitochondria in a tissue-specific manner. Calorie restriction (CR) is, so far, the only intervention able to delay or prevent the onset of several age-related changes also in mitochondria. Using livers from middle age (18-month-old), 28-month-old and 32-month-old ad libitum-fed and 28-...

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Main Authors: Picca, Anna, Pesce, Vito, Fracasso, Flavio, Joseph, Anna-Maria, Leeuwenburgh, Christiaan, Lezza, Angela M. S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772924/
https://ncbi.nlm.nih.gov/pubmed/24058615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074644
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