Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart

The well-known age-related mitochondrial dysfunction deeply affects heart because of the tissue’s large dependence on mitochondrial ATP provision. Our study revealed in aged rat heart a significant 25% decrease in mtDNA relative content, a significant 29% increase in the 4.8 Kb mtDNA deletion relati...

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Bibliografiska uppgifter
I publikationen:Free Radic Biol Med
Huvudupphovsmän: Chimienti, Guglielmina, Picca, Anna, Sirago, Giuseppe, Fracasso, Flavio, Calvani, Riccardo, Bernabei, Roberto, Russo, Francesco, Carter, Christy S., Leeuwenburgh, Christiaan, Pesce, Vito, Marzetti, Emanuele, Lezza, Angela Maria Serena
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319621/
https://ncbi.nlm.nih.gov/pubmed/29969715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.06.041
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