The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo/phagosomes into lysosomes by a process called maturation. Maturation is driven by the phosphoinositide kinase PIKfyve. Blocking PIKfyve activity by small molecule inhibit...

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Pubblicato in:iScience
Autori principali: Baranov, Maksim V., Bianchi, Frans, Schirmacher, Anastasiya, van Aart, Melissa A.C., Maassen, Sjors, Muntjewerff, Elke M., Dingjan, Ilse, ter Beest, Martin, Verdoes, Martijn, Keyser, Samantha G.L., Bertozzi, Carolyn R., Diederichsen, Ulf, van den Bogaart, Geert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319320/
https://ncbi.nlm.nih.gov/pubmed/30612035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.12.015
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