The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo/phagosomes into lysosomes by a process called maturation. Maturation is driven by the phosphoinositide kinase PIKfyve. Blocking PIKfyve activity by small molecule inhibit...

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Publicado en:iScience
Main Authors: Baranov, Maksim V., Bianchi, Frans, Schirmacher, Anastasiya, van Aart, Melissa A.C., Maassen, Sjors, Muntjewerff, Elke M., Dingjan, Ilse, ter Beest, Martin, Verdoes, Martijn, Keyser, Samantha G.L., Bertozzi, Carolyn R., Diederichsen, Ulf, van den Bogaart, Geert
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319320/
https://ncbi.nlm.nih.gov/pubmed/30612035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.12.015
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