Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains unclear. In this study, we demonstrated the critical role of nuclear factor erythroid 2-rel...

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Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Jin, Yao, Huang, Zhen-lin, Li, Li, Yang, Yang, Wang, Chang-hong, Wang, Zheng-tao, Ji, Li-li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318309/
https://ncbi.nlm.nih.gov/pubmed/29921882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0024-8
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