Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling

Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in multiple lines of normal cells. Neverth...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Li, Huachao, Chen, Yueming, Zhang, Jiahao, Chen, Xiangcui, Li, Zheng, Liu, Bing, Zhang, Luyong
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337349/
https://ncbi.nlm.nih.gov/pubmed/30597971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24010110
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk