Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling

Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) plays an important role in alleviating APAP hepatic toxicity. Shikonin (SHK) enhances Nrf2 in multiple lines of normal cells. Neverth...

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Gepubliceerd in:Molecules
Hoofdauteurs: Li, Huachao, Chen, Yueming, Zhang, Jiahao, Chen, Xiangcui, Li, Zheng, Liu, Bing, Zhang, Luyong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6337349/
https://ncbi.nlm.nih.gov/pubmed/30597971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24010110
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