Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity

Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2-related factor 2 (Nrf2) is involved in prevention of hepatotoxicity. Although Licochalcone A (Lico A) upregulates Nrf2 signaling...

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Foilsithe in:Front Pharmacol
Main Authors: Lv, Hongming, Xiao, Qingfei, Zhou, Junfeng, Feng, Haihua, Liu, Guowen, Ci, Xinxin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2018
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876234/
https://ncbi.nlm.nih.gov/pubmed/29628888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00147
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