Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains unclear. In this study, we demonstrated the critical role of nuclear factor erythroid 2-rel...

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Опубликовано в: :Acta Pharmacol Sin
Главные авторы: Jin, Yao, Huang, Zhen-lin, Li, Li, Yang, Yang, Wang, Chang-hong, Wang, Zheng-tao, Ji, Li-li
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318309/
https://ncbi.nlm.nih.gov/pubmed/29921882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0024-8
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