Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway

Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains unclear. In this study, we demonstrated the critical role of nuclear factor erythroid 2-rel...

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Publicat a:Acta Pharmacol Sin
Autors principals: Jin, Yao, Huang, Zhen-lin, Li, Li, Yang, Yang, Wang, Chang-hong, Wang, Zheng-tao, Ji, Li-li
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318309/
https://ncbi.nlm.nih.gov/pubmed/29921882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0024-8
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