Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant activation of signaling pathways driving cellular proliferation, survival, and therapeutic resistance. Although pancreatic ductal adenocarcinoma (PDA) has historically been refractory to kinase inhibition, therap...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Allen-Petersen, Brittany L., Risom, Tyler, Feng, Zipei, Wang, Zhiping, Jenny, Zina P., Thoma, Mary C., Pelz, Katherine R., Morton, Jennifer P., Sansom, Owen J., Lopez, Charles D., Sheppard, Brett, Christensen, Dale J., Ohlmeyer, Michael, Narla, Goutham, Sears, Rosalie C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318036/
https://ncbi.nlm.nih.gov/pubmed/30389701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0717
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