Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant activation of signaling pathways driving cellular proliferation, survival, and therapeutic resistance. Although pancreatic ductal adenocarcinoma (PDA) has historically been refractory to kinase inhibition, therap...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Allen-Petersen, Brittany L., Risom, Tyler, Feng, Zipei, Wang, Zhiping, Jenny, Zina P., Thoma, Mary C., Pelz, Katherine R., Morton, Jennifer P., Sansom, Owen J., Lopez, Charles D., Sheppard, Brett, Christensen, Dale J., Ohlmeyer, Michael, Narla, Goutham, Sears, Rosalie C.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318036/
https://ncbi.nlm.nih.gov/pubmed/30389701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0717
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