Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant activation of signaling pathways driving cellular proliferation, survival, and therapeutic resistance. Although pancreatic ductal adenocarcinoma (PDA) has historically been refractory to kinase inhibition, therap...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Allen-Petersen, Brittany L., Risom, Tyler, Feng, Zipei, Wang, Zhiping, Jenny, Zina P., Thoma, Mary C., Pelz, Katherine R., Morton, Jennifer P., Sansom, Owen J., Lopez, Charles D., Sheppard, Brett, Christensen, Dale J., Ohlmeyer, Michael, Narla, Goutham, Sears, Rosalie C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318036/
https://ncbi.nlm.nih.gov/pubmed/30389701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0717
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