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Structural mechanisms of selectivity and gating in anion channelrhodopsins

Both designed and natural anion-conducting channelrhodopsins (dACRs and nACRs, respectively) have been widely applied in optogenetics (enabling selective inhibition of target-cell activity during animal behaviour studies), but each class exhibits performance limitations, underscoring trade-offs in c...

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הוצא לאור ב:	Nature
Main Authors:	Kato, Hideaki E., Kim, Yoon Seok, Paggi, Joseph M., Evans, Kathryn E., Allen, William E., Richardson, Claire, Inoue, Keiichi, Ito, Shota, Ramakrishnan, Charu, Fenno, Lief E., Yamashita, Keitaro, Hilger, Daniel, Lee, Soo Yeun, Berndt, Andre, Shen, Kang, Kandori, Hideki, Dror, Ron O., Kobilka, Brian K., Deisseroth, Karl
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2018
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6317992/ https://ncbi.nlm.nih.gov/pubmed/30158697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0504-5
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Structural mechanisms of selectivity and gating in anion channelrhodopsins

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