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Structural mechanisms of selectivity and gating in anion channelrhodopsins

Both designed and natural anion-conducting channelrhodopsins (dACRs and nACRs, respectively) have been widely applied in optogenetics (enabling selective inhibition of target-cell activity during animal behaviour studies), but each class exhibits performance limitations, underscoring trade-offs in c...

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Bibliografiske detaljer
Udgivet i:Nature
Main Authors: Kato, Hideaki E., Kim, Yoon Seok, Paggi, Joseph M., Evans, Kathryn E., Allen, William E., Richardson, Claire, Inoue, Keiichi, Ito, Shota, Ramakrishnan, Charu, Fenno, Lief E., Yamashita, Keitaro, Hilger, Daniel, Lee, Soo Yeun, Berndt, Andre, Shen, Kang, Kandori, Hideki, Dror, Ron O., Kobilka, Brian K., Deisseroth, Karl
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6317992/
https://ncbi.nlm.nih.gov/pubmed/30158697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0504-5
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